Pharmacovigilance and side effects
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Oncology

Carbomedac

Product Description

The cytostatic drug carboplatin is a platinum derivative that acts by cross-linking DNA strands through platinisation. This leads to impaired transcription and replication of DNA, inhibition of protein biosynthesis and apoptosis. The substance has a non-specific effect on cell cycle phases.

Active Ingredient

Carboplatin

Mode of Action

Carboplatin has biochemical properties similar to those of cisplatin, thus producing predominantly interstrand and intrastrand DNA crosslinks. Carboplatin exhibited comparable activity to cisplatin against a wide range of tumours regardless of implant site. Alkaline elution techniques and DNA binding studies have demonstrated the qualitatively similar modes of action of carboplatin and cisplatin. Like cisplatin, carboplatin induces changes in the superhelical structure of the DNA, consistent with a ‘DNA-shortening effect’.

Indication

  • Advanced ovarian cancer
  • Small cell carcinoma of the lung

Dosage

Concentrate for solution for infusion:

  • 50 mg (5 ml)
  • 150 mg (15 ml)
  • 450 mg (45 ml)
  • 600 mg (60 ml)
  • 1000 mg (100 ml)

Not all pack sizes may be marketed.

Materials

Abbreviated product information

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