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Oncology

Lomustine medac

Product Description

As part of a combination therapy with procarbazine and vincristine (PCV regimen), Lomustine is the standard of care in most lower WHO grade gliomas with IDH mutation (oligodendrogliomas, astrocytomas). In addition, Lomustine is the main standard of care for recurrent glioblastomas.

Active Ingredient

Lomustine

Mode of Action

Lomustine is a nitrosourea and spontaneously decomposes into a chloroethyl carbonium ion via the chloroethyldiazonium ion after oral administration. The cytostatic effect is due to the alkylation of the O6 of guanine by the chloroethylcarbonium ion. In addition, bifunctional alkylation (by two reactive sites) leads to cross-linking of DNA and induction of apoptosis. Lomustine can penetrate the blood-brain barrier and is therefore suitable for the treatment of brain tumours.

Indication

As palliative or supplementary treatment, usually in combination with radiotherapy and/or surgery as part of multiple drug regimens:

  • Brain tumours (primary or metastatic)
  • Small cell lung cancer
  • Hodgkin’s disease (resistant to conventional combination chemotherapy)
  • Malignant melanoma (metastatic)
  • Non-Hodgkin lymphoma

Dosage

Hard capsules:

  • 40 mg

Medicamento sujeito a pedido de Autorização de Utilização Especial emitida pelo INFARMED

Not all pack sizes may be marketed.

Materials

Abbreviated product information

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