Sodiofolin

Active Ingredient

Disodium folinate

Mode of Action

Folinic acid is the formyl derivative of tetrahydrofolic acid or the active form of folic acid. It is involved in various metabolic processes, including purine synthesis, pyrimidine nucleotide synthesis and amino acid metabolism.

Biochemical basis for the combination of folinic acid, disodium salt and fluorouracil: By binding thymidilate synthetase, fluorouracilinter alia inhibits DNA synthesis. The combination of folinic acid, disodium salt and fluorouracil leads to the formation of a stable ternary complex consisting of thymidilate synthetase, 5-fluorodeoxyuridine monophosphate and 5,10-methylenetetrahydrofolate.

This leads to a sustained blockade of thymidilate synthetase with increased inhibition of DNA biosynthesis, resulting in increased cytotoxicity compared to monotherapy with fluorouracil.
This leads to an extended blockade of thymidilate synthetase with enhanced inhibition of DNA biosynthesis, resulting in increased cytotoxicity as compared to 5-fluorouracil monotherapy.

Administration

• Intravenous infusion
• Intravenous injection

Indication

• To diminish the toxicity and counteract the action of folic acid antagonists such as methotrexate in cytotoxic therapy and overdose in adults and children.
• Cytotoxic therapy in combination with 5-fluorouracil.

Dosage

Solution for injection/infusion: 

• 100 mg (2 ml)
• 200 mg (4 ml)
• 300 mg (6 ml)
• 400 mg (8 ml)
• 500 mg (10 ml)
• 900 mg (18 ml)

Not all pack sizes may be marketed.